Endocrine Abstracts

Objectives: Generously supported by IPSEN)-->It is known that the obesity and insulin resistance are an integral part of acromegaly. The aim of study was to evaluate the role of octreotide LAR treatment on BMI in patients with acromegaly.Methods: Sixteen patients with acromegaly diagnosed at Endocrinology Clinic in Sarajevo (10 females and 6 males, mean age 53.4±6.3 years, age range 38–65 years, six p...

Aim: To investigate the efficacy of octreotide LAR therapy in acromegalic patients as primary or secondary therapy.Methods: Ten acromegalic patients diagnosed at Clinic of Endocrinology in Sarajevo (seven females and three males, mean age 55.2±7.2 years, age range 40–65 years, five patients with microadenoma and five patients with macroadenoma) were treated with octreotideLAR. Operated were 60% of patients. Concentration of hGH and IGF1 was eva...

Background: PCOS is the most common endocrinopathy in women of reproductive age, characterized by hyperandrogenism and ovulatory dysfunction. The aim of this study was to evaluate the effects of metformin therapy on hirsutism, androgen and metabolic parameters in PCOS women.Methods: Fifty PCOS women with hirsutism aged 20–40 years were included in the study. PCOS diagnosis was made after excluding other causes of hirsutism and in accordance with Rot...

Aim: The aim of study was to explore the effects of subclinical hypothyroidism (SH) treatment in PCOS women with metabolic syndrome (MS) and PCOS women without MS.Methods: The 34 PCOS women were divided in two groups: 1) PCOS women with SH and the MS (n=23, age 32.9±9 years, BMI=31.2±3.1 kg/m2; waist size=87 cm) and 2) PCOS women with SH without MS (n=11, age 30.5±7.5 years, BMI=23.4±1.5 kg/m2; wais...

Aims: The aim of study was to evaluate glucose control in obese diabetics during six months of treatment with glargin insulin in combination with metformin and glimepirid.Methods: In beginning of study excluded patients who had coronary heart and kidneys disease before. In study included 43 obese diabetics with type 2 diabetes [23 male and 20 female, BMI=29.82±1.91 kg/m2, aged 42–65 yr], who had previously been treated with different...

The polycystic ovary syndrome (PCOS) is characterized by insulin resistance with compensatory hyperinsulinemia. Insulin resistance also plays a role in the metabolic syndrome. PCOS women with metabolic syndrome have more hyperandrogenism and menstrual cycle irregularity than women with PCOS only.The aim of the study was to determine the difference in the level of lipids, CRP, androgens and prolactins between PCOS women with metabolic syndrome and PCOS wo...

The aim of this study was to evaluate our clinical experience in the treatment of acromegaly during 5-year follow-up period.Methods: Seventeen acromegaly patients (11 women and six men) monitored during 5-year follow-up period. A level of GH of <2.5 ng/ml and the normal IGF range were considered as the criterion for remission. The GH level and IGF1 level were evaluated every 6 months, while magnetic resonance imaging was taken every year during follo...

Background: Serum cystatin C is a novel marker for kidney function that has been claimed to be superior to serum creatinine. Cystatin C concentrations increased in the hyperthyroid patients and decreased in the hypothyroid patients. The cystatin C test detects kidney disease at earlier stages, before symptoms appear and creatinine levels rise. Another advantage is that, unlike creatinine, blood levels of cystatin C are less influenced by age, gender, race, or lean muscle mass,...

A 66 years old woman on orthopedic clinic, was resection of tibias tumor in both legs because was suspicion of primary bone neoplasm or metastases (X-ray showed osteolytic lesion). Histology was: osteitis fibrosa cystica - Brown tumor. After resection the patient was referred to the endocrinologist because of persistently high calcemia (3.3 mmol/l). Blood tests showed normal CRP but elevated alkaline phosphatase of 173 U/l. Phosphate was low at 0.75 mmol/l (0.81–1.58). Pa...

Introduction: Dietary therapy (DT), programmed physical activity (PPA) and cognitive-behavioural therapy (CBT) are basic measures in the treatment of obesity. CBT applies methods which change eating habits of obese persons, aiming to remove barriers relating DT and PPA. The goal of this study is to try efficiency of applying CBT in the programme for the reduction of body mass of obese persons, vs the application of DT and PPA alone.Design: The study incl...